Although we are very good friends I_George.A. have nothing in common withB. have something in common withC. have nothing in commonD. have much in common with

此题考察的是短语“have nothing in common with”和“have something in common with”的用法。前者表示“与某人没有共同点”，后者表示“与某人有共同点”。根据题干中的“Although we are very good friends”，可以推测出尽管他们是好朋友，但可能在某些方面没有共同点。因此，正确答案是A选项。