46. After her appointment ___ this important position, she had to work in the office until late in the evening and had no time for her former friends.A. withB. toC. overD. at

本题考查知识点为固定搭配的用法。解题思路是根据常见的英语表达习惯来判断哪个介词与“appointment”搭配是正确的。

在英语中，“appointment to”表示“被任命到某个职位”，这是一个固定的搭配用法。而“appointment with”通常表示“与某人的预约”；“appointment over”和“appointment at”都不是常见的正确搭配。

所以，根据固定搭配的规则，这里应该用“to”。